The early life condition - A translational study of affective and behavioral outcomes and genetic modulation
Main content
Adverse experiences durineg early life are quite prevalent in our society. Individuals who experience stress in early life appear to develop pathologic changes that increase vulnerability to stressful life events in later life, predisposing them to development of multiple forms of (severe) psychopathology. The primary objective of this project is to establish translational research on early life stress with affective, behavioral outcome as well as genetic modulation, with a strong gender perspective.
The secondary objectives are:
- to explore the impact of negative experiences in childhood,
- to explore the impact of positive support as a moderator of risk to develop later anxiety and depression
- to identify high-probability candidate genes which may interact with early life stress making the individual more vulnerable or resilient to later stress experience. The latter point represents an innovative approach to the exploration of genetic vulnerability and resilience of early life stress.
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Publications from this project
Steine IM, Skogen JC, Krystal JH, Winje D, Milde AM, Gr酶nli J, Nordhus IH, Bjorvatn B, Pallesen S听(2019)听. Child Abuse Negl. 93:263-276.
Steine IM, Winje D, Skogen JC, Krystal JH, Milde AM, Bjorvatn B, Nordhus IH, Gr酶nli J, Pallesen S. (2017). Child Abuse Negl 67:280-293
Steine IM, Zayats T, Stansberg C, Pallesen S, Mrdalj J, Havik B, Soule J, Haavik J, Milde AM, Skrede S, Murison R, Krystal J, Gronli J. (2016). Transl Psychiat 6(12):e977
Steine IM, Winje D, Nordhus IH, Milde AM, Bjorvatn B, Gr酶nli J, Pallesen S. (2016) Tidsskrift for Norsk Psykologforening 53(11): 888-899
Mrdalj J, Murison R, Soule J, Rod AMK, Milde AM, Pallesen S, Gronli J. (2016). Physiol Behav 165: 313-321
Mrdalj J, Lundegaard Mattson A, Murison R, Konow Jellestad F, Milde AM, Pallesen S, et al. (2014). Chronobiol Int 31(2): 252-64
Mrdalj J, Pallesen S, Milde AM, Jellestad FK, Murison R, Ursin R, et al. (2013). PLoS One 8(7): e69923
Steine IM, Krystal JH, Nordhus IH, Bjorvatn B, Harvey AG, Eid J, et al. (2012). J Interpers Violence 27(9): 1827-43
Steine IM, Harvey AG, Krystal JH, Milde AM, Gronli J, Bjorvatn B, et al. (2012). Sleep Med Rev 16(1): 15-25
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Doctoral degrees
Jelena Mrdalj. The early life condition. Importance for sleep, circadian rhythmicity, behaviour and response to later life challenges. Link for
Iris Mulders Steine.听Predictors of symptoms outcomes among adult survivors of sexual abuse: The role of abuse characteristics, cumulative childhood maltreatment, genetic variants, and perceived social support.
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